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The TLR2 inhibitor C29 (MedChem Express, HY-100461) was administered at 30 mg/kg in vehicle (saline, 20 mM sodium bicarbonate) via intraperitoneal (ip) injection immediately after surgery and then daily until day 3 post-surgery

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Further experimental validation in animal models of osteoporosis and prospective clinical studies are essential to determine whether such effects translate into meaningful improvements in bone mass or fracture risk

Its prolonged activity makes it a focus compound for studying sustained growth factor signaling

Osmotic laxatives such as macrogol and bulk-forming laxatives like ispaghula husk are safe for long-term use under medical supervision