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The primary functions attributed to gut-derived serotonin were regulation of gastrointestinal motility and gastrointestinal secretory processes
Mitochondrial dysfunction additionally leads to a structural alteration in the adenine nucleotide translocator protein when it interacts with Cyclophilin D
The primary cause for alarm is thyroid C-cell hyperplasia, which has been the subject of FDA boxed warnings since a research conducted on rats showing dose-dependent C-cell tumors (Madsen et al
Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN: Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress
similar mechanisms may apply
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