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The role of insulin-like growth factor binding proteins in metabolic syndrome Recall that IGFBPs have a very important role, not only in modulating free IGF-1, half-life and localisation, but also by possessing IGF-independent activities mediated by their own receptors
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Since the peptide promotes blood vessel formation, questions arise about whether it could support tumor growth in people with existing cancers
Lauterburg BH et al
As MOTS-c activates AMPK and NRF2, it also indirectly suppresses the mTOR (mechanistic target of rapamycin) pathway, the master growth and anabolism regulator that, when chronically overactivated, accelerates the accumulation of senescent cells
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