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Genetic predispositions in the GLP1R pathway (variant rs6923761) may correlate with differential receptor sensitivity, suggesting some patients respond effectively at lower starting doses while others require gradual titration to therapeutic levels
Regulatory bodies are increasingly approving GLP-1 therapies for obesity-specific indications
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The authors advocate tailored monitoring protocols, including gradual dose titration at initiation and periodic renal function assessment in elderly patients to optimise safety outcomes in clinical practice
doi: 10.3390/nu12113304
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