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Epidemiological data linking higher IGF-1 levels within the normal range to modestly increased cancer incidence inform this caution

PMID: 33473342 11 Treatments of trimethylaminuria: where we are and where we might be heading

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Contraindications to semaglutide include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, and previous serious hypersensitivity to semaglutide or any formulation components

Patients who switched from tirzepatide to orforglipron maintained a mean 74.7% of their body weight reduction from the SURMOUNT-5 trial compared with those in the placebo group, which maintained a mean 49.2% of their weight loss