The weight reduction benefit with GLP-1 RAs, used as a monotherapy or in combination with other glucose-lowering therapies, has been demonstrated in various studies (Fig
and a combined form in which both junctional and nodular patterns occur [15, 55, 56]
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A comprehensive approach focuses on restoring appropriate metabolic signaling so that improvements in weight, energy, and overall health are sustainablewhether GLP-1 medications are used temporarily, long-term, or not at all
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