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Study population We prospectively enrolled 61 non-ambulatory SMA children at six centers in North America
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Clinicians should monitor for signs of pancreatitis (severe abdominal pain), gallbladder disease, and diabetic retinopathy worsening in susceptible patients
The dysregulated activation of microglia leads to infiltration of the brain by macrophages under pathological conditions 55
Key Findings from the Clinical Trial The study, led by Christian Hendershot at USC's Institute for Addiction Science, showed that weekly injections of semaglutide compared to placebo: Reduced alcohol cravings significantly Decreased drinking quantity overall Lowered the frequency of heavy drinking days What makes these results particularly exciting is that the magnitude of semaglutide's effects appeared potentially greater than what is typically seen with existing FDA-approved medications for alcohol use disorder, even though the drug was only administered at the lowest clinical doses
