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Their primary mode of action involves binding to ergosterol, a key sterol component of fungal cell membranes, leading to the formation of pores that disrupt membrane integrity and cause leakage of intracellular ions such as Na + , K + , H + , and Cl - , ultimately inhibiting fungal growth (Gray et al., 2012
Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity
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Most experts say up to 500 mg per day for a couple of months is generally well tolerated.
Protein shakes can help when solid food feels difficult to manage, especially in the first few days after a dose increase
