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fiber supports microbiota producing SCFAs that improve metabolic signaling and inflammation HPA axis : regulate stress to prevent cortisol-driven dysglycemia and hedonic eating Nutrient status : adequate protein, omega-3s, magnesium, micronutrients for mitochondrial and metabolic health Inflammation resolution : movement, sleep, and whole foods modulate cytokine tone, supporting insulin signaling and ovarian function Fertility and PCOS: Restoring Ovulation Through Metabolic Repair As insulin normalizes: SHBG rises

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Ensure they perform baseline testing (GH stimulation, IGF-1), demonstrate reconstitution techniques, and supervise dose titration

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Pregnancy and lactation represent additional contraindications due to the absence of safety data in these populations