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Possible glutathione risks and side effects include: Allergic reactions Skin rashes, itching, or swelling at the injection site, particularly with lower quality glutathione brands Kidney strain High dose glutathione administered over extended periods without medical supervision can place stress on kidney function Thyroid interference Some studies suggest excessive glutathione use may affect thyroid hormone levels over time Nerve damage Rare but documented in cases where injections were administered incorrectly by untrained practitioners Skin irregularities Uneven whitening or patchy skin tone when sessions are inconsistent or self-administered Infection risk Any intravenous treatment carries infection risk if sterile protocols are not strictly followed The single most effective way to minimize all these glutathione injection side effects is to choose a certified aesthetic clinic with qualified medical staff, verified product sourcing, and proper clinical protocols

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Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible

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