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Endpoint choice matters because a biomarker improvement is not the same as an approved clinical outcome

Caring for your minerals is very important

Its often temporary, especially in the first few weeks or after a dose change

Guidance such as the ADA/EASD Management of hyperglycaemia in type 2 diabetes consensus report (Davies et al, 2022) recommends early initiation of GLP-1 RAs or SGLT2 inhibitors along with metformin in those with established or high risk of cardiovascular disease, and it is usual practice to titrate one drug up fully before adding the second class, without waiting for further glycaemic assessment

Tirzepatide is an effective medication approved by the U.S