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Mitochondrial complex I is considered one of the primary sources of ROS and increased oxidative stress resulting from ROS production is one of the proposed mechanisms for the death of dopaminergic neurons in PD 23

This means the problem is not only not enough fuel, but also broken machinery. GSH (Glutathione) depletion links directly to vascular dysfunction, neuropathy, nephropathy, and retinopathy

Lu H, Xie L, Guo L, Gu X, Zhu R, Yang Y, Tang F, Li M, Liu C, Wang D, Li M, Tian Y, Cai S