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The most common side effects appear to be related to the method of administration, which is typically intramuscular or subcutaneous injection
doi:10.1042/bj0310645
At this stage, the most defensible position is that timing likely plays a minor role compared to overall exposure and consistency
Historically, PAs were implicated in the etiology of schizophrenia because certain antipsychotic and antimalarial drugs contain structural components resembling spermidine and were associated with extrapyramidal symptoms and psychosis (84)
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