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PT-141 was specifically designed to activate the same MC4R pathway that causes erections, so switching to PT-141 doesn't eliminate erectile effects

(Long-term cardiovascular outcomes trial that does not gate initial obesity approval but informs any later cardiovascular indication.) Jastreboff AM, Kaplan LM, Frias JP, et al

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Oxidative stress leads to metabolic problems in the membrane lipids, DNA, RNA, and the increased risk of seizures and recurrent seizures 39