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[PMID: 9336832] PubMed record related to this compound for laboratory literature review

Polymorphisms of Nav1.6 sodium channel, brain-derived neurotrophic factor, catechol-O-methyltransferase and guanosine triphosphate cyclohydrolase 1 genes in trigeminal neuralgia

Researchers suggest that elevated gut pH, gut dysbiosis (i.e., a higher Firmicutes : Bacteroidetes ratio), obesity, or malabsorption might increase fecal SCFA, such as butyrate, which could have potential neurotoxic effects [25, 45, 46]

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Your individual metabolism affects durationfaster metabolizers may need more frequent dosing