When used as monotherapy, tirzepatide has a very low risk of causing clinically significant hypoglycemia (less than 0.6% incidence), similar to placebo, due to its glucose-dependent mechanism of action that limits insulin secretion when blood sugar approaches normal levels
The total running time was 12 min: 01 min, 50% solvent B, 19 min, 5040% solvent B, 910 min, 40% solvent B, 1010.1 min, 4050% solvent B, followed by column re-equilibration with 50% solvent B for 1.9 min
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Medication adherence is critical for sustained benefits