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This has led many people to ask a clear and sensible question: what is retatrutide, and why is it being studied so closely

BMJ 370 , m3324 (2020)

IGF-1 LR3s markedly reduced IGFBP affinity allows researchers to study sustained, IGFBP-independent IGF-1R signalling in a way that is not practically achievable with native IGF-1

These possible adverse outcomes should be considered alongside the potential metabolic health benefits during the decision-making process for each individual considering metabolic surgery (Arterburn 2020)