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Addition of the ISR agonist Sephin1 to cultured human OLmaintained under control conditions or exposed to ongoing metabolic stressreduced process outgrowth 42 , suggesting that the ISR regulates the protein synthesis machinery required for OL process outgrowth and maintenance

Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover

In this trial, the weight lost in the extract group came from fat, with no drop in estimated muscle mass by BIA [4]

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