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According to FDA prescribing information, approximately 20% of participants experience gastrointestinal side effects with either medication, while 60-75% of patients report at least one adverse event of any type

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Phase 1a studies in healthy volunteers, published in Diabetes, Obesity and Metabolism in 2023, established the compound's single-dose and multiple-dose pharmacokinetics, confirming a half-life supportive of once-daily dosing, a favorable food-effect profile, and dose-proportional exposure across the tested range