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all mechanistic and efficacy evidence is animal-derived or anecdotal, placing overall confidence at Low to Very Low for systemic human claims

Loading phases use 2-5mg twice weekly for four weeks

Any references to appetite signaling, energy expenditure, satiety, or food intake are limited to experimental research context only and do not imply approved human or veterinary use

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Initial laboratory assessment should include a complete blood count and serum vitamin B12 level