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Extension Phase (Weeks 26-52) : In the double-blind Extension Phase, patients on tesamorelin completing the 26-week Main Phase were re-randomized to receive 2 mg tesamorelin or placebo

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GLP-1RA as a treatment for T2DM has been reported to reduce AGEs production and thus decrease the risk of diabetes complications

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15 ROS include radical compounds, such as superoxide, hydroxyl radicals, and lipid hydroperoxides, and reactive nonradical compounds, such as singlet oxygen, hydrogen peroxide (H 2 O 2 ), hypochlorous acid, chloramines, and ozone