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Preventive Services Task Force focus on lifestyle modification: Caloric restriction : Creating a 500-750 kcal/day deficit through reduced intake Physical activity : At least 150 minutes of moderate-intensity aerobic exercise weekly, plus resistance training Behavioral interventions : Structured programs addressing eating behaviors, self-monitoring, and psychological factors Dietary patterns : Mediterranean, DASH, or plant-based diets with emphasis on whole foods, fiber, and nutrient density These interventions typically produce 5-10% body weight loss over 6-12 months when implemented consistentlymodest but clinically meaningful for reducing cardiovascular and metabolic risk

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According to the drug label, Wegovy is contraindicated (should not be used) in the following populations: Individuals with a known sensitivity to semaglutide or other ingredients in Wegovy Individuals with a personal or family medical history of medullary thyroid cancer (MTC) Individuals with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Wegovy is also not approved for use in pediatric patients under 12 years old or pregnant people

doi: 10.1128/mBio.01476-14 20 BoldriniMCanollPDKleinRS

Another Spanish study showed that the combination therapy reduced HbA1c by 1.1% and weight by 3.5 kg weight loss in 212 patients for 16.46.5 months [9]