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Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors

When supplements that also lower blood sugar or affect gastrointestinal motility are added to the mix, the combined effects may become excessive

Lin H, Tsai Y, Liao P, Wei JC

First, BAs are passively absorbed by interacting with and activating TGR5 receptors on enteric neurons

Mice were studied as described in Figure 1A, and pancreatic sections were costained for insulin and glucagon