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Symptoms could include a rash or hives

Published safety data shows negative results in repeated-dose toxicity studies, skin irritation protocols, sensitization assays, and genotoxicity testing

When meat is seared or potatoes are fried, AGEs are created (Uribarri 2010)

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In vitro and in vivo studies suggest that these compounds induce mitochondrial dysfunction, oxidative stress, and apoptosis of human hepatocytes (Hep2G).[1,2] Animal studies suggest that kava's vasodepressor activity is mediated by a GABA receptorsensitive pathway.[3] Kavapyrones also demonstrated additive effects with the serotonin 1A agonist, ipsapirone