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As integral components of the NVU, perivascular astrocytes maintain BBB characteristics by contributing to basement membrane formation, regulating pericyte differentiation, and modulating EC functions by regulating the expression of TJs such as claudin-5, occludin, and ZO-1 [49, 51,52,53]

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Once a pen is open and in use, it can be kept at room temperature (below 30C) or in the fridge for up to 30 days away from light

therefore, avoid using it during pregnancy or breastfeeding Bipolar disorder : Acetyl-L-carnitine might worsen symptoms in people with bipolar disorder who are in the remission state