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Symptoms of deep vein thrombosis (DVT) typically affect the legs and may include: Swelling in one leg, ankle, or foot Pain or tenderness, often starting in the calf Warmth in the affected area Red or discolored skin Unexplained leg pain, especially with unilateral symptoms Symptoms of pulmonary embolism (PE) , which occurs when a clot travels to the lungs, constitute a medical emergency and include: Sudden shortness of breath or difficulty breathing Sharp chest pain that worsens with deep breathing or coughing Rapid heart rate or palpitations Coughing up blood Lightheadedness or fainting Symptoms of arterial thrombosis (stroke or heart attack) require immediate emergency care: Sudden weakness or numbness, especially on one side of the body Difficulty speaking or understanding speech Sudden severe headache Chest pain, pressure, or discomfort Pain radiating to the arm, jaw, or back While these symptoms are not specifically associated with tirzepatide, any patient experiencing them should seek immediate medical evaluation regardless of their medication regimen

Even brain microglia , the immune cells of the central nervous system, express GLP-1 receptors