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CD4 + T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 + T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

That changed after chemist Bruce Merrifield developed solid-phase peptide synthesis, a breakthrough that earned him the Nobel Prize in 1984 and dramatically simplified production of these fragile biomolecules by allowing them to be built much more efficiently compared to purification

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It also protects existing collagen from oxidative degradation slowing the breakdown of the protein that keeps skin firm and elastic