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Abstract Glucagon-like peptide-1 (GLP-1) is a gut hormone mainly produced in the intestinal epithelial endocrine L cells, involved in maintaining glucose homeostasis
[6] There is no official evidence that tirzepatide causes physical dependence or withdrawal symptoms in the traditional sense, but the underlying metabolic conditions will reassert themselves without ongoing pharmacological support
Observational studies have demonstrated that individuals with obesity are at substantially higher risk of developing lymphoedema following cancer treatment, and those with established lymphoedema experience greater symptom burden and functional impairment when overweight or obese
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