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It wasnt uncommon for me to get emails from patients telling me that they couldnt keep anything down because they were so nauseous after their first injection

This differs from some peptides where dosing scales with body mass

Overdose Information for Tresiba An excess of insulin relative to food intake, energy expenditure, or both may lead to severe and sometimes prolonged and life threatening hypoglycemia and hypokalemia [see WARNINGS AND PRECAUTIONS ]

Kunji, E

That creates demand for products that are not just "healthy" in a broad sense, but better aligned with a smaller appetite and a more deliberate meal structure