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Under these conditions, eNOS changes the nitric oxide free radical to a superoxide anion due to reduced tetrahydrobiopterin (BH4) or L-arginine (L-Arg) levels [71]

2020 Mar;8(3):e2

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Consistently, GSTP-S184D also showed higher efficiency than GSTP (WT) in preventing LPS-induced HMGB1 export from the nucleus to cytoplasm in RAW264.7 cells, while GSTP-S184A almost had no effect on that (Figure 5B)