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International Council for Harmonisation

Available long-term data: Limited data beyond 12 weeks of continuous use No long-term safety concerns identified in available data Both peptides are based on naturally occurring compounds Theoretical profile favorable for extended use Long-term recommendations: Consider cycling on and off for very extended use Enhanced monitoring for protocols beyond 12 weeks Periodic assessment of continued need Documentation of long-term outcomes Theoretical long-term concerns: No major concerns identified Both peptides work with natural healing processes No evidence of tolerance or dependence No withdrawal effects on discontinuation Comparison to Alternative Treatments The safety profile compares favorably to alternatives

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However, how BPC 157 regulates the vasomotor tone and intracellular Src-Caveolin-1 (Cav-1)-eNOS signaling is not yet clear