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Tirzepatide is a dual GIP and GLP1 receptor agonist given as a once-weekly injection that improves insulin response, slows digestion, reduces appetite, and supports significant weight loss when combined with lifestyle changes

241 In a study in mice fed a high-fat diet, treatment with gypenosides (active compounds from gynostemma) had positive effects on the gut microbiome, as well as gene expression, that may have contributed to its ability to increase thermogenesis and adipose tissue browning, reduce weight gain, and exert other metabolic benefits

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