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The only human pharmacokinetic and pharmacodynamic trial data for CJC-1295 DAC comes from Teichman et al
Animal studies demonstrate that IGF-1 treatment reduces circulating free fatty acid levels, potentially through increased muscle uptake and oxidation combined with reduced adipose tissue lipolysis
This allows assessment of tolerance before increasing to standard therapeutic doses of 1-2mg daily
PMID 7811344
P.KirkpatrickB.FischerB
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