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Although some GLP-1RAs do not seem to naturally cross the bloodbrain barrier, they may still reach relevant brain areas via circumventricular sites and, possibly, via active transporters 4,5

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20 This observation emphasizes their potential to promote systemic metabolic health beyond glucose homeostasis and makes GLP-1RAs a more suitable treatment option for T2D patients with a higher risk of cardiovascular disease compared to metformin

On that note, Dr

Adequate fiber prevents constipation, feeds beneficial gut bacteria, stabilizes blood sugar, and creates satiety from smaller portions