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[PMID: 1592062] PubMed record related to this compound for laboratory literature review
For example, ROS can facilitate the extrinsic apoptosis pathway through negative regulation of the cellular FLICE-inhibitory protein (Wang et al., 2008) and can induce intrinsic apoptosis pathways by triggering quick release of Cyt-c (Madesh and Hajnoczky, 2001) and regulating the Bcl-2 protein family (Li et al., 2011), and AMPK can be activated by AMPK kinase after H 2 O 2 treatment, which also results in autophagy induction ( Given the strong relationship between ROS and cell death, regulating ROS generation upward or controlling oxidative defense downward has become central for new cancer treatments, which have been enhanced by the finding that cancer cells process a higher level of ROS than do healthy cells (Tafani et al., 2016), can lead to two opposite outcomes: the promotion of cancer and its suppression
Hyperphosphorylation of the tau protein can be mediated by activation of the p38MAPK/p53 signaling pathway (Sun et al., 2017)
Glutathione and Aging One of the leading theories on aging states that organisms age because cells accumulate free radical damage over time
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