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In drug-resistant ovarian cancer cells, exogenous uptake becomes the primary source of cholesterol, with decreased expression of farnesyl bisphosphate synthase (FDPS) and oxidized squalene cyclase (OCS) involved in endogenous cholesterol synthesis, and increased expression of low-density lipoprotein receptor (LDLR) promoting exogenous cholesterol uptake (62)
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Evidence for these combinations is sparser and more productspecific
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That dual-action design is exactly why it has become such a closely watched molecule in metabolic research
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