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Once a KwikPen is pierced or removed from the fridge for room-temperature storage, it must be thrown away after 30 days, regardless of how many doses are left inside

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There have been reports of pulmonary aspiration (when food or liquid from the stomach enters the lungs) in people taking GLP-1 medications, including Zepbound while undergoing surgery requiring sedation, even when instructed to fast before the surgery

(2019) 317:E61730

It acts through monocarboxylate transporters on orexin neurons, and this effect is mediated by ATPsensitive potassium channels composed of Kir6.1 and SUR1 subunits, thus influencing wakefulness and energy homeostasis (Parsons and Hirasawa, 2010)