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18 GLP-1 RAs were initially approved by the FDA for the treatment of type 2 diabetes based on phase 3 trials demonstrating superiority in reducing hemoglobin A 1c and improving cardiovascular outcomes compared with other antihyperglycemic medications

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Lee H et al

tirzepatide access Online Weight Loss Treatment Tirzepatide in Ohio  From

The terminal half-life was determined based on the terminal slope, which was obtained by converting the micro-constants from the 2-compartment model to macro constants ( 03hr ) was obtained by integrating the curve over this time period, while the total AUC (AUC 0- ) was derived using the dose divided by clearance

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