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The underlying mechanism is unclear, and hypotheses include changes in retinal blood flow and hemodynamics and upregulation of vascular endothelial growth factor, leading to retinal neovascularisation

Three reviewers (RZ, QH, PS) graded the strength of evidence as high, moderate, low and very low degree, following five assessment criteria which were risk of bias, inconsistency, indirectness, publication bias, and imprecision

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Common reactions include injection site redness, swelling, or bruising