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Similarly, SOD WT misfolds and develops a similar conformation to mutant SOD1, leading to aggregation and the gain of toxic functions in vitro (Bosco et al., 2010
Biomedicines 11 , 1745 (2023)
The kidneys and liver are particularly vulnerable to senescent cell accumulation because of their high metabolic activity and constant exposure to circulating toxins
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In a second step, glutathione synthase (GshB) adds a glycine to the C-terminus of this dipeptide, resulting in -glutamyl-cysteinyl-glycine (glutathione) (Apontoweil and Berends, 1975
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