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Participants who received orforglipron started the study at a dose of 1 milligram daily and then increased the dose every four weeks to their final maintenance dose

4 Mao X, Zhang X, Henry L, et al

B12 deficiency can come from vegetarian diets, certain medications such as Metformin, and a condition called pernicious anemia wherein the body lacks intrinsic factor, which is necessary for the absorption of B12.

The reactive oxygen species then donates one electron to a glutathione molecule, completing the oxidation-reduction reaction and rendering it unable to perform oxidative damage to the cell