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Weight changes were modest, typically between a 2 to 6 pound loss over six months
Can I switch from orlistat to Wegovy or Mounjaro
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More serious but less common adverse effects from these medications include: Blockage in the intestine or bile duct Gallstones Gastroparesis (delayed stomach emptying) Pancreatitis (inflammation of the pancreas) These medications also carry a black box warning that they may increase the risk for thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)
Further, ingestion of a mixed carbohydrate and fat meal significantly increases plasma GIP levels compared to carbohydrates alone in healthy humans ( GIP concentrations in the bloodstream are the highest in hepatic portal plasma, however, lymph GIP concentrations are 3-fold higher upon the same stimulus (Lu et al., 2008), indicating peptide transit from K cells to villus lacteals
