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the morning hypofibrinolytic and hypercoagulable state, in combination with increased PAI-1 levels, may contribute to less effective tPA treatment in the morning
Acta Physiol (Oxf) (2009) 196(1):1526
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SAGE Journals Narrative and scoping reviews summarize improved healing in tendon/ligament, muscle, bone, and GI mucosa models, with encouraging signals but limited controlled human data to date
The tissue lacks the robust blood supply that muscles enjoy, receives constant mechanical loading that disrupts healing, and often develops fibrotic scar tissue rather than healthy organized collagen
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