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Another active site residue of the small subunit (Asp445 in BsGGT) reported to interact with the -amino group of donor substrate has also been suggested to have a putative role in substrate binding (Minami et al., 2003a)

Notably, the mechanisms of probiotics may involve modulation of gut microbiota composition, while prebiotics such as inulin-type fructans (ITF) can selectively promote the growth of beneficial bacteria like Bifidobacterium and Lactobacillus, enhancing SCFA production and subsequently improving gut barrier function, insulin sensitivity, and metabolic parameters (99, 110)

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Marzetti, E., R

533 These findings underscore the role of Metrnl in regulating energy homeostasis in diabetes