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Eventually, enough bonds break that the remaining intact molecules cannot produce adequate receptor activation

According to the UK SmPC, these include: Nausea : Very common, affecting 11.9-24.0% of patients (dose-dependent), particularly during the initial weeks of treatment or following dose increases

White race correlated with later plateau while Asian race predicted earlier stabilization

Licensed indication : The same active ingredient may be marketed under different brand names for diabetes versus obesity (e.g., Ozempic vs Wegovy for semaglutide), with different pricing structures

Contraindications: Hypersensitivity to semaglutide or any of its excipients