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Clinical data sourced from published tirzepatide trials
Triple-Agonist Mechanism of Action GLP-1 Pathway (Glucagon-Like Peptide-1) Activates receptors in the hypothalamus to reduce appetite, stimulates insulin secretion from pancreatic beta cells, and slows gastric emptying
Glucagon administration also decreases hepatic triacylglycerol synthesis in rats [56] and stimulates hormone-sensitive lipase in human and rat white adipocytes to promote lipolysis and the release of NEFA [57, 58]
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