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Dysfunctional brain insulin signaling has been shown using blood-neuron-derived extracellular vesicles, whereby PD patients display altered IRS1 phosphorylation, which is further correlated with tremor severity [158]
That is a meaningfully weaker claim than the titles phrasing implies, and it is the claim the evidence actually supports
Orforglipron, developed by Lilly, is also a type of GLP-1 agonist, but its a smaller molecule that doesnt need to be digested by your stomach
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J Biol Chem 259(22):1408214087
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