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A 2016 study of Expert Review of Respiratory Medicine concluded that doses of NAC greater than 1,200 mg per day could help prevent acute exacerbations in those with COPD, which is important as many with chronic lung disease end up in hospitals during an acute attack

This pattern makes sense when you understand the mechanism

With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels

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