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Single-point energies were calculated on the optimized geometries using the B97X-D hybrid functional 87 and the 6-311 + G(2d,p) basis set with ultrafine integration grids for the QM part and the ff14SB, gaff2 and TIP3P force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding

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Who It Is For Patients with stubborn visceral fat that resists diet and exercise Men and women experiencing metabolic slowdown associated with aging Patients with insulin resistance or metabolic syndrome who want to improve metabolic markers Anyone seeking meaningful body recomposition not just weight loss, but shifting the ratio of fat to lean mass Patients who have plateaued on a weight loss program and need a metabolic reset What to Expect Weeks 1-4: Improved energy and exercise tolerance as mitochondrial function improves