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Ferroptosis in drug resistance in cancer Despite significant advances in cancer treatment, drug resistance remains a major clinical challenge

SIRT1 also inactivates p53 which is involved in neuronal cell death (Kim et al

& Jaenisch, R

Dysfunctional mitochondria in neutrophils, macrophages, and T lymphocytes alter cytokine production, phagocytic activity, and antigen presentation, tipping the balance toward excessive inflammation or postoperative immunosuppression, thereby exacerbating organ injury

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